Supplementary Figure S3 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Key Points

• T-cell dependency plays a crucial role in tumor regressions and complete responses in pancreatic ductal adenocarcinoma.
• The study highlights significant effects of ras(on) multi-selective inhibition on stroma and vasculature in PDAC tumors.
• Preclinical models were utilized to assess how ras(on) influences tumor dynamics and immune interactions.
• Understanding these mechanisms may advance therapeutic strategies for pancreatic ductal adenocarcinoma treatment.

Abstract