Abstract C087: Analysis of the chromatin accessibility landscape in patients with localized prostate cancer

Abstract Significant group-based variations in prostate cancer (PCa) outcomes represents a critical healthcare challenge in the USA. African American (AA) men face the highest incidence of PCa and are twice as likely to succumb to their disease compared to their Caucasian American (CA) counterparts. This disparity stems from a complex interplay involving social, environmental, and biological factors. While inequitable access to quality healthcare is a key contributor, even in settings with equal care, AA patients more often present with advanced disease at diagnosis, suggesting unique tumor biology. While some understanding of the epigenomic landscape has been recently identified, the full extent of global chromatin remodeling contribution towards differences in health outcomes across population groups remains poorly understood. To better elucidate how chromatin remodeling and gene regulation influences PCa development across CA and AA population groups, we employed single-cell spatial transposase-accessible chromatin technology followed by sequencing (scATAC-seq) and H3K27ac spatial-CUT 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr C087.