What question did this study set out to answer?

This research aims to characterize CD8+ T cell responses to cancer therapy using immunoPET.

December 10, 2025Open Access

89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4

Key Points

This research aims to characterize CD8+ T cell responses to cancer therapy using immunoPET.
Used anti-CD8 immunoPET for imaging immune responses.
Performed immunohistochemistry on tumor tissue samples.
Utilized an orthotopic mouse model of breast cancer.
Confirmed the presence of heterogeneous CD8+ T cell responses.
Documented an early immune response after combination treatment.
Imaging effectively detected these immune responses.

Abstract

Anti-CD8 immunoPET facilitates non-invasive, whole-body visualization of immune responses, and syngeneic preclinical models are a crucial tool for studying tumor infiltration of T cells in response to cancer therapies. This study characterized longitudinal CD8+ T cell responses in an orthotopic mouse model of breast cancer treated with radiation and anti-CTLA4 by immunohistochemistry and anti-CD8 immunoPET, confirming an early but heterogeneous response induced by combination treatment that is detectable by imaging.

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Authors

Elizabeth Germino

Kirstin A. Zettlitz

Tyler Watkins

Journals

npj Imaging

Actions

Institutions

City Of Hope National Medical Center

City of Hope

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89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4

Key Points

Abstract

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Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

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