Understanding drug-target residence time and the implications on drug discovery

Key Points

• The aim is to explore how residence time and binding affinity together enhance drug discovery.
• Integration of residence time with traditional binding assays
• Analysis of pharmacodynamic efficacy
• Evaluation of target selectivity and safety
• Optimizing residence time leads to improved pharmacodynamic efficacy
• Enhanced target selectivity is achieved through residence time optimization
• Residence time is identified as a significant kinetic parameter in drug discovery

Abstract