Two previously undescribed iridoid glycosides, paedoside I (1) and paedoside J (2), were isolated from the aerial parts of Paederia foetida. The structures of these compounds, especially their absolute configurations, were elucidated by comprehensive spectroscopic analysis and chemical methods. Compounds 1 and 2 were tested for cytotoxicity, hepatoprotective activity, and inhibitory effects on NO production in LPS-activated microglia, and 2 exhibited hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage.
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Wanqi Zhang
Chinese Academy of Medical Sciences & Peking Union Medical College
Xiaoze Li
Chinese Academy of Medical Sciences & Peking Union Medical College
Ming-Hui Sun
Chinese Academy of Medical Sciences & Peking Union Medical College
Journal of Asian Natural Products Research
Chinese Academy of Medical Sciences & Peking Union Medical College
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Zhang et al. (Wed,) studied this question.
synapsesocial.com/papers/6980fcfcc1c9540dea80ec79 — DOI: https://doi.org/10.1080/10286020.2026.2622452
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