Abstract PS1-01-25: Let’S talk about sexuality in cancer care: a cross-sectional analysis of a multicenter survivorship program

Abstract Background: Sexual dysfunction is a highly prevalent yet frequently underrecognized and undertreated issue among breast cancer survivors (BCS). Despite its impact on quality of life, discussions and management strategies are often lacking in routine care. This study examines post-treatment sexual symptoms, their association with emotional well-being, and partner relationships in BCS. Methods: We analyzed data from breast cancer survivors enrolled in “OC sobre VIVER”, a multicenter survivorship program coordinated by the Oncoclínicas Group (Brazil), representing one of the few structured survivorship care models in Latin America. Participants were 3-18 months post-active treatment. Structured interviews assessed sexual symptoms (vaginal dryness, dyspareunia, low libido), emotional status (self-esteem, depression, anxiety), and partner communication. Data was managed via REDCap. Descriptive and bivariate analyses were performed using GraphPad Prism, version 10. Results: From July 2023-March 2025, 391 women (median age 50 years range: 30-86) were enrolled. Of 376 women with staging data, 360 (95%) had invasive breast cancer (stage I: 55%, II: 33%, III: 12%). Notably, 92% (349/381) expressed a desire to address sexual health concerns during clinical encounters. Sexual dysfunction was prevalent: low libido in 67% (253/376), vaginal dryness in 65% (236/363), and dyspareunia in 31% (116/374). Psychosocial findings included low self-esteem in 31% (118/383) of participants, anxiety in 58% (225/387), and depression in 27% (104/387). Poor partner communication (among partnered) was reported in 10% (27/264). Dyspareunia was significantly associated with anxiety symptoms (p = 0.0003), but not with cancer stage, depression, or communication quality (p 0.05). Low libido was more frequent with low self-esteem (75% vs. 64%, p = 0.043), higher stage (stage III: 15% vs. 4%, p = 0.008), hormonotherapy use (71% vs. 56%, p = 0.012) and showed a trend toward higher prevalence with poor partner communication (78% vs. 63%, p = 0.143). No associations with age, relationship status, or chemotherapy use (p 0.05). Conclusions: Sexual symptoms were highly prevalent in this BCS cohort and encompassed both physical and psychosocial factors, including emotional distress and partner communication. These findings highlight critical opportunities for intervention. Routine assessment of sexual health and the integration of tailored, multidisciplinary strategies should be prioritized in survivorship care. Citation Format: C. Chiodi, F. Santos Dumont Sorice, T. Santana, F. Oliveira, M. Mathias Machado, R. Brant Costa, M. de Azevedo Kalile, C. Pavei, M. Borges Bittencourt, D. Strassburger Nunes, H. Pantoja, T. de Melo Passarini, M. Couto, M. Behrends Pinto, C. Perini, C. Cerqueira Mathias, M. Laloni, M. Cruz Rangel Silva, C. Alves Costa e Silva, L. Landeiro. Let’S talk about sexuality in cancer care: a cross-sectional analysis of a multicenter survivorship program abstract. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS1-01-25.