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March 3, 2026
GCSH promotes colorectal cancer progression by inhibiting Cuproptosis through the PI3K/AKT-FDX1 axis
XG
Xianwen Guo
JL
Jiao Li
LS
Liqi Shen
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Key Points
Colorectal cancer progression is enhanced by GCSH's inhibition of cuproptosis, impeding cell death.
GCSH's impact was correlated with changes in fdx1 expression, showing significant molecular interactions.
Assessment using molecular pathway analysis highlighted the role of the PI3K/AKT axis in cancer advancement.
Findings may enable new therapeutic strategies targeting GCSH to combat colorectal cancer.
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GCSH promotes colorectal cancer progression by inhibiting Cuproptosis through the PI3K/AKT-FDX1 axis | Synapse
Cite This Study
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Guo et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75affc6e9836116a218a5
https://doi.org/https://doi.org/10.1007/s10142-025-01808-6