Viable sperm DNA fragmentation index (SDF) provides better diagnostic accuracy than total SDF in male infertility: a cross-sectional study

Key Points

• Functional sperm DNA damage is better assessed using viable sperm DNA fragmentation index than total sperm assessment.
• Specifically evaluating membrane-intact sperm offers a more accurate diagnosis of male infertility than broader tests.
• Observational analysis highlights the importance of viable sperm in understanding fertility-related DNA damage.
• Clinical assessment may benefit from focusing on sperm viability to enhance infertility diagnostics.