Gut Microbiota, Lipidome, and Metabolites Mediate Immune Dysregulation in Diabetic Microvascular Disease: A Two-sample Mendelian Randomization and Mediation Analysis

Key Points

Immune dysregulation is linked to gut microbiota and lipidome in diabetic microvascular disease.
Mediation analysis using Mendelian randomization reveals significant causal pathways among plasma metabolites.
Previous studies on metabolic pathways highlight the role of gut bacteria in influencing immune responses.
Identifying these pathways may enable therapeutic targets for treating immune-related complications.

Abstract

Using causal inference approaches, this study identifies immune cell-mediated mechanisms underlying DMiVD, involving gut microbiota, plasma lipids, and metabolites. The results suggest potential intervention targets for mechanistic studies and therapeutic development.

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Cite This Study

Zhao et al. (Tue,) studied this question.

synapsesocial.com/papers/69a75c1ec6e9836116a249e2 https://doi.org/https://doi.org/10.2174/0118715303418611251125045911

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