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Tannins from Phyllanthus niruri: α-Glucosidase Inhibition Mechanism and Molecular Interaction Analysis | Synapse
March 3, 2026
Tannins from Phyllanthus niruri: α-Glucosidase Inhibition Mechanism and Molecular Interaction Analysis
AM
Ana M. Gonzalez Miragliotta
EA
Emilio Angelina
National University of the Northeast
GO
G. P. Ojeda
National University of the Northeast
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Key Points
The study demonstrates a significant inhibition of α-glucosidase activity, indicating potential therapeutic properties of tannins.
A molecular interaction analysis shows detailed binding sites and mechanisms involved, with implications for diabetes management.
Assessment using molecular docking techniques reveals specific interactions between tannins and the enzyme α-glucosidase.
Understanding the inhibition mechanism may pave the way for new treatments based on plant-derived compounds.
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Miragliotta et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75c91c6e9836116a258c2
https://doi.org/https://doi.org/10.1007/s43450-025-00735-8
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