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March 3, 2026
Open Access
Designing Future Cardiac Arrest Trials to Accommodate Heterogeneous Treatment Effects
GL
Gabriele Lileikyte
McGill University Health Centre
LM
Lucas L. Marinho
McGill University Health Centre
PM
Peter J. McGuigan
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Key Points
Heterogeneous treatment effects may influence outcomes significantly in cardiac arrest.
Key evidence suggests that variations in treatment response can alter patient survival rates in trials.
Trial design should accommodate these differences to enhance the reliability of outcomes in cardiac arrest studies.
This analysis supports the need for tailored interventions for diverse patient populations during trials.
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Lileikyte et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75ccdc6e9836116a25fc2
https://doi.org/https://doi.org/10.1016/j.jacadv.2025.102571
Designing Future Cardiac Arrest Trials to Accommodate Heterogeneous Treatment Effects | Synapse