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Reply: non-significant results do not imply similarity or safety in NC-FET follicle-size comparisons: a clarification | Synapse
March 3, 2026
Open Access
Reply: non-significant results do not imply similarity or safety in NC-FET follicle-size comparisons: a clarification
JZ
J. Zhang
Shanghai Jiao Tong University
LW
Ling Wu
Shanghai Jiao Tong University
Key Points
Non-significant results do not ensure safety or similarity in clinical outcomes, emphasizing caution in interpretation.
The commentary highlights the need for careful analysis of follicle size data in NC-FET contexts.
A clear distinction between statistical non-significance and clinical relevance is critical for patient safety.
Lack of significant findings should not be misinterpreted as a guarantee of safety; further investigation is necessary.
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Zhang et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75eccc6e9836116a29bbe
https://doi.org/https://doi.org/10.1093/hropen/hoag008