Ginkgetin attenuates oxidative stress–induced apoptosis and osteoarthritis progression via the PI3K/Akt signaling pathway–mediated upregulation of Bcl-2
Key Points
Ginkgetin reduces oxidative stress and apoptosis in osteoarthritis, which may slow disease progression.
Key evidence shows upregulation of Bcl-2 correlates with improved outcomes in oxidative stress conditions.
Assessment using the PI3K/Akt signaling pathway indicates a mechanism for ginkgetin's effects on apoptosis.
Findings suggest ginkgetin may serve as a therapeutic agent, but further studies are required to confirm results.
Ginkgetin attenuates oxidative stress–induced apoptosis and osteoarthritis progression via the PI3K/Akt signaling pathway–mediated upregulation of Bcl-2 | Synapse