Charge-dependent interfacial mechanism and conformational dynamics of lipase immobilization on ZIF-8: Insights from MD simulation and experiments

Key Points

• Lipase immobilization on ZIF-8 reveals crucial charge-dependent interfacial mechanisms.
• The study demonstrates significant conformational dynamics influenced by the ZIF-8 framework.
• Molecular dynamics simulations and experimental approaches validate the insights gained.
• The findings may enhance strategies for enzyme immobilization in various biotechnological applications.