Apoptosis induction and enhanced CASP9 expression in liver cancer cells by crocin-conjugated magnetite iron oxide nanoparticles

Key Points

• Apoptosis induction increased in liver cancer cells treated with crocin-conjugated nanoparticles, suggesting a promising therapeutic strategy.
• Enhanced CASP9 expression was observed, linking it to improved cell death via the apoptotic pathway in these cancer cells.
• The approach used crocin-conjugated magnetite iron oxide nanoparticles, focusing on their role in inducing cell death effects.
• This study underscores the potential for magnetic nanoparticles in cancer therapy, requiring further validation in clinical settings.