Palmitic acid-evoked PKR/JNK activation and SIRT1 decline: Association with myocardial ageing phenotype changes and partial reversal by inhibitors | Synapse
March 3, 2026
Palmitic acid-evoked PKR/JNK activation and SIRT1 decline: Association with myocardial ageing phenotype changes and partial reversal by inhibitors
Key Points
Activation of the PKR/JNK pathway is linked to changes in the myocardial ageing phenotype.
Palmitic acid treatment led to a decline in SIRT1 levels alongside increased PKR and JNK activation.
Inhibitors of PKR and JNK demonstrated potential to partially reverse ageing phenotype alterations.
These findings highlight potential therapeutic strategies for addressing myocardial ageing.