Targeted deep sequencing identifies mosaicism in patients with immune dysregulation

Key Points

• Mosaicism is identified in patients experiencing immune dysregulation, highlighting a crucial genetic aspect.
• Targeted deep sequencing reveals 15% of samples exhibit significant genetic variation, indicating complexity in immune response.
• The method utilized is targeted deep sequencing, allowing for in-depth genetic analysis and identification of subtle variations.
• Findings may enable more precise diagnostics and therapeutic strategies by uncovering underlying genetic factors.