High-throughput discovery and characterisation of pentafluorobenzene sulfonamide modifiers of Aurora A kinase | Synapse
March 18, 2026Open Access
High-throughput discovery and characterisation of pentafluorobenzene sulfonamide modifiers of Aurora A kinase
Key Points
To explore how pentafluorobenzene sulfonamides can modify Aurora A kinase and enhance our understanding of its function.
High-throughput screening for covalent modifiers of Aurora A kinase
Characterization of modifications for functional analysis
Successful identification of novel pentafluorobenzene sulfonamide compounds
Enhanced understanding of Aurora A kinase modulation through covalent modification
Abstract
Covalent modification, by substitution of pentafluorobenzene sulfonamides, can enable understanding and modulation of protein function, and the identification of new therapeutic opportunities.