PAK5-Mediated Suppression of β-Hydroxybutyrate Production Promotes Breast Cancer Metastasis and Can Be Overcome with Ketogenic Diet

Key Points

• To investigate the role of PAK5 in breast cancer metastasis through β-hydroxybutyrate production.
• Analyzed the phosphorylation effects of PAK5 on HMGCS2.
• Evaluated breast cancer growth and metastasis in relation to β-hydroxybutyrate levels.
• Explored the impact of a ketogenic diet on these pathways.
• PAK5 phosphorylation of HMGCS2 was found to inhibit β-hydroxybutyrate production.
• Inhibition of β-hydroxybutyrate significantly promoted breast cancer metastasis.
• A ketogenic diet showed potential to counteract the effects of PAK5 on β-hydroxybutyrate levels.