Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Key Points

• The research aims to examine the relationship between cannabis and tobacco use and brain volume specifically focusing on key brain regions.
• Conducted a systematic review and meta-analysis of existing literature.
• Analyzed studies measuring brain volume in relation to cannabis and tobacco usage.
• Identified specific brain regions impacted by substance use.
• Cannabis use is linked to a smaller volume in the amygdala.
• Tobacco use is associated with reduced volumes in the amygdala, insula, pallidum, and total grey matter.

Abstract