Titration of nicotine intake in smokers switching to reduced nicotine content cigarettes with access to alternative nicotine systems: Secondary analysis of a randomized clinical trial

Key Points

• This analysis investigates how smokers adjust their nicotine intake when switching to low nicotine content cigarettes with alternative nicotine delivery options.
• Secondary analysis of data from a randomized clinical trial
• Evaluation of nicotine intake adjustments among smokers
• Comparison of effects of alternative nicotine delivery systems
• Most smokers used alternative nicotine delivery systems to supplement their intake
• High levels of nicotine titration were observed among participants
• Wider access to alternative systems may increase acceptance of nicotine reduction measures

Abstract