MMP-Responsive Bioactive Glass-Incorporated Hydrogels with Enhanced Antibacterial and Angiogenic Performance for Infected Wound Healing

Key Points

• The aim is to develop hydrogels that can respond to MMPs for better healing of infected wounds.
• Created MMP-responsive hydrogels incorporated with bioactive glass
• Assessed antibacterial performance through bacterial cultures
• Evaluated angiogenic effects using cellular assays
• Hydrogels showed significant antibacterial activity against common wound pathogens
• Enhanced angiogenesis was observed in treated wounds compared to controls
• Demonstrated improved healing metrics in MMP-rich environments

Abstract