Effective extraction and determination of 9 β-lactams in water and milk samples by a novel magnetic covalent organic framework combined with UPLC-MS/MS | Synapse
April 10, 2026Open Access
Effective extraction and determination of 9 β-lactams in water and milk samples by a novel magnetic covalent organic framework combined with UPLC-MS/MS
Key Points
To design and synthesize a magnetic covalent organic framework for extracting β-lactams from water and milk samples.
Synthesis of Fe 3 O 4 @SiO 2 @Ap-COF as adsorbent
Utilization of magnetic solid-phase extraction (MSPE)
Application of UPLC-MS/MS for detection
Successfully extracted 9 different β-lactams from the samples
Demonstrated efficient adsorption capability of the magnetic framework
Provided clear evidence of β-lactam presence in analyzed samples
Abstract
A novel magnetic covalent organic framework Fe 3 O 4 @SiO 2 @Ap-COF was designed and synthesized, which was used as an adsorbent for magnetic solid-phase extraction (MSPE) for the determination of 9 β-lactams.