Does pravastatin reduce platelet thrombus formation in hypercholesterolemia?
Subjects with hypercholesterolemia
Pravastatin
Platelet thrombus formation at high and low shear ratessurrogate
Cholesterol lowering with pravastatin decreases platelet thrombus formation, suggesting a mechanism by which it reduces the risk of acute coronary events.
Thus, hypercholesterolemia is associated with an enhanced platelet thrombus formation on an injured artery, increasing the propensity for acute thrombosis. Platelet thrombus formation at both high and low shear rates decreased as total and LDL cholesterol levels were reduced with pravastatin. Cholesterol lowering may therefore reduce the risk of acute coronary events in part by reducing the thrombogenic risk.
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Lucie Lacoste
Jules Y.T. Lam
Joseph Hung
Circulation
Queen Elizabeth II Medical Centre
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Lacoste et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69d9097762c2da40083afd84 — DOI: https://doi.org/10.1161/01.cir.92.11.3172
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