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Detectable plasma HPV DNA at end of CRT predates the clinical diagnosis of metastases and is associated with inferior progression-free survival. Moreover, 3-month plasma HPV DNA level is more accurate than 3-month FDG-PET imaging in detecting residual disease. The clinical utility of plasma HPV DNA detection for guiding adjuvant/salvage therapy should be evaluated in future studies.
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Kathy Han
Eric Leung
Lisa Barbera
JCO Precision Oncology
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Han et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69d98ea32a25b240b7a3cdd3 — DOI: https://doi.org/10.1200/po.18.00152