What question did this study set out to answer?

The research aims to assess gadolinium retention and release mechanisms in inflamed brain tissue using EPR techniques.

April 15, 2026Open Access

EPR-based Assessment of Gadolinium-based Contrast Agent Retention and Gadolinium Transchelation in Inflamed Murine Brain

Key Points

The research aims to assess gadolinium retention and release mechanisms in inflamed brain tissue using EPR techniques.
Utilized EPR and ENDOR to detect Gd³⁺ release within brain tissue
Conducted analyses in both in vivo and ex vivo settings
Examined the relationship between inflammation and Gd retention
Found inflammation promotes significant gadolinium retention
Highlighted potential underestimation of Gd accumulation by conventional MRI
Characterized retained gadolinium species within intact brain tissue

Abstract

EPR and ENDOR proved to be sensitive methods for detecting Gd³⁺ release and characterizing retained Gd species within intact brain tissue. Our findings demonstrate inflammation-promoted Gd retention, underscore the importance of integrating in vivo and ex vivo analyses to unravel mechanisms of long-term Gd retention, and suggest that conventional MRI may underestimate the true extent of Gd accumulation, especially under neuroinflammatory conditions.

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Authors

Lina Anderhalten

Nicole Höfer

Daria Dymnikova

Journals

Investigative Radiology

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EPR-based Assessment of Gadolinium-based Contrast Agent Retention and Gadolinium Transchelation in Inflamed Murine Brain

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

References and Citations

Citation Network

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