What question did this study set out to answer?

The aim is to explore the link between Benzo[a]pyrene exposure and gastric cancer, focusing on ESR1 as a potential biomarker.

April 15, 2026Open Access

Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzoapyrene exposure to gastric cancer risk

Key Points

The aim is to explore the link between Benzo[a]pyrene exposure and gastric cancer, focusing on ESR1 as a potential biomarker.
Utilized integrated computational toxicology approaches.
Conducted immune profiling to analyze immune features.
Identified ESR1 as a pivotal connection between exposure and cancer risk.
ESR1 was identified as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk.
Both toxicological impact and immune features were shown to be influenced by ESR1.

Abstract

In conclusion, our integrated computational study provides preliminary evidence suggesting ESR1 as a potential hub linking BaP exposure to gastric cancer risk, possibly via influencing immune features. This identifies ESR1 as a candidate biomarker and reveals a testable hypothesis for future mechanistic investigation.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Chenglin Wang

Yaxing Deng

Rui Yang

Journals

Discover Oncology

Actions

Institutions

Affiliated Hospital of Southwest Medical University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzoapyrene exposure to gastric cancer risk

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider