Sex- and Pubertal Stage-Specific Bone Microarchitecture and Strength in Adolescents With Type 1 Diabetes

Key Points

• To investigate how sex and pubertal stage influence bone microarchitecture and strength in adolescents with type 1 diabetes.
• Comparative analysis of bone microarchitecture between boys and girls with type 1 diabetes
• Focus on mid-pubertal and early-pubertal stages
• Assessment of trabecular and cortical bone strengths
• Mid-pubertal boys exhibited trabecular and cortical deficits leading to reduced bone strength
• Early-pubertal girls showed no deficits in bone strength
• Mid-puberty in boys is identified as a critical period for potential interventions

Abstract