Intravascular large B-cell lymphoma can mimic hypersensitivity pneumonitis and exhibit temporary spontaneous regression, delaying diagnosis if malignancy is not considered.
73-year-old man with intravascular large B-cell lymphoma (IVLBCL) presenting with fever and bilateral ground-glass opacities mimicking hypersensitivity pneumonitis
Transbronchial lung cryobiopsy and chemotherapy
Intravascular large B-cell lymphoma can mimic hypersensitivity pneumonitis and exhibit temporary spontaneous regression, emphasizing the need for tissue biopsy when clinical improvement is not sustained.
Intravascular large B-cell lymphoma (IVLBCL) is a rare and often fatal malignancy that presents with non-specific pulmonary symptoms and abnormal imaging findings. We report a unique case of IVLBCL in a 73-year-old man who initially presented with fever and bilateral ground-glass opacities on computed tomography that mimicked hypersensitivity pneumonitis. The symptoms temporarily improved with environmental antigen avoidance, which delayed a correct diagnosis. Ultimately, transbronchial lung cryobiopsy confirmed IVLBCL, and chemotherapy was effective. This case highlights the potential for spontaneous regression of IVLBCL and the importance of considering malignancy when clinical improvement is not sustained.
Building similarity graph...
Analyzing shared references across papers
Loading...
Takuya Ozawa
Satoshi Okamori
Tomoya Uchida
Respiratory Investigation
Saiseikai Utsunomiya hospital
Building similarity graph...
Analyzing shared references across papers
Loading...
Ozawa et al. (Sat,) reported a other. Intravascular large B-cell lymphoma can mimic hypersensitivity pneumonitis and exhibit temporary spontaneous regression, delaying diagnosis if malignancy is not considered.
www.synapsesocial.com/papers/69e7138bcb99343efc98cfec — DOI: https://doi.org/10.1016/j.resinv.2026.101427