A systematic review evaluated currently available therapeutic modalities, including drug-eluting stents and drug-coated balloons, for the management of in-stent restenosis.
Systematic Review
This systematic review summarizes current therapeutic modalities, including DES and drug-coated balloons, for the challenging management of in-stent restenosis.
Management of patients with in-stent restenosis (ISR) remains an important clinical problem. Although drug-eluting stents (DES) have drastically reduced the incidence of ISR, treatment of DES-ISR is particularly challenging. ISR mainly results from aggressive neointimal proliferation, but recent data also suggest that neoatherosclerosis may play an important pathophysiological role. Intracoronary imaging provides unique insights to unravel the underlying substrate of ISR and may be used to guide repeated interventions. In this paper, we systematically reviewed clinical trial data with currently available therapeutic modalities, including DES and drug-coated balloons, in patients presenting with ISR within bare-metal stents or DES.
Alfonso et al. (Sun,) conducted a systematic review in In-stent restenosis. Drug-eluting stents and drug-coated balloons was evaluated. A systematic review evaluated currently available therapeutic modalities, including drug-eluting stents and drug-coated balloons, for the management of in-stent restenosis.