What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Obstructive Sleep Apnea and Post-Myocardial Infarction. Intervention: Obstructive Sleep Apnea. Primary outcome: All-Cause Mortality.

What question did this study set out to answer?

This study aims to clarify the relationship between obstructive sleep apnea and mortality following acute myocardial infarction.

May 8, 2026Open Access

Association Between Obstructive Sleep Apnea and Post-Myocardial Infarction All-Cause Mortality: A Systematic Review and Meta-Analysis

Key Result

The provided text is an author checklist and does not contain the study results or findings.

Key Points

This study aims to clarify the relationship between obstructive sleep apnea and mortality following acute myocardial infarction.
Systematic review and meta-analysis of studies from six databases.
Statistical analyses used included random-effects models for adjusted odds ratio and adjusted hazard ratio.
Included 13 studies totaling 7,044,777 individuals for analysis.
Short-term post-MI mortality was lower among individuals with OSA (aOR=0.67; 95% CI 0.61–0.74).
OSA was associated with a 53% increased risk of long-term mortality (aHR=1.53; 95% CI 1.22–1.92).
No evidence of publication bias was detected by Egger’s test.

Study Design

Type

Meta-Analysis

Structured PICO

Does obstructive sleep apnea affect short- and long-term all-cause mortality in patients following acute myocardial infarction?

Population

7,044,777 individuals following acute myocardial infarction across 13 studies (6 studies with n=7,032,232 for short-term outcomes; 7 studies with n=12,545 for long-term outcomes)

Intervention

Presence of obstructive sleep apnea (OSA)

Comparator

Absence of obstructive sleep apnea

Outcome

All-cause mortality (short-term defined as in-hospital or ≤30-day; long-term defined as minimum follow-up of 3 months)hard clinical

Obstructive sleep apnea is associated with a paradoxical decrease in short-term mortality but a significant increase in long-term mortality following acute myocardial infarction.

Abstract

Objectives: Evidence regarding the association between obstructive sleep apnea (OSA) and mortality following acute myocardial infarction (MI) remains inconsistent. This study aimed to clarify this relationship through a systematic review and meta-analysis.Methods: A comprehensive search of six international databases (PubMed, Scopus, Web of Science, ScienceDirect, Google Scholar, and Embase) was conducted on November 11, 2024, without time restrictions. Statistical analyses included a random-effects model stratified by adjusted odds ratio (aOR) and adjusted hazard ratio (aHR). Short-term mortality was defined as in-hospital or ≤30-day mortality, whereas long-term mortality referred to outcomes assessed after a minimum follow-up of 3 months. Data synthesis was performed using Comprehensive Meta-Analysis software (Version 2).Results: Six studies, including a total of 7,032,232 individuals, showed that short-term post–acute MI mortality was lower among individuals with OSA (aOR=0.67; 95% confidence interval CI 0.61–0.74). In contrast, pooled analysis of seven additional studies (n=12,545) reporting aHR indicated that OSA was associated with a 53% increased risk of long-term mortality (aHR=1.53; 95% CI 1.22–1.92). Egger’s test showed no evidence of publication bias.Conclusions: OSA did not show a significant association with increased short-term post-MI mortality in aOR-based analyses but was linked to a higher risk of long-term mortality in aHR-based analyses. This discrepancy may reflect methodological differences, including the absence of time-to-event modeling in aOR and the greater sensitivity of aHR, as well as variations in study design and follow-up duration. Further well-designed studies are required to confirm these findings.

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Cite This Study

Salari et al. (Thu,) conducted a meta-analysis in Obstructive Sleep Apnea and Post-Myocardial Infarction. Obstructive Sleep Apnea was evaluated on All-Cause Mortality. The provided text is an author checklist and does not contain the study results or findings.

synapsesocial.com/papers/69fd7eb0bfa21ec5bbf06fce https://doi.org/https://doi.org/10.13078/jsm.250025

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