Structure-Activity Relationships of ATCUN-Based Cu(II) Complexes with Large Chelate Rings: Interplay of ROS Generation, DNA Binding, and Nuclease Activity

Key Points

• This research aims to explore the relationship between the structure of ATCUN-based Cu(II) complexes and their biological activities, particularly in DNA interaction and ROS generation.
• Evaluated various Cu(II) ATCUN derivatives.
• Assessed their DNA binding affinity and nuclease activity.
• Measured levels of reactive oxygen species (ROS) generation.
• Certain Cu(II) complexes showed enhanced DNA cleavage activity compared to the simplest GGH complex.
• ROS generation was significantly increased by specific Cu(II) complexes, correlating with nucleolytic activity.