Vitiligo in a case of vaccinia virus-treated melanoma

nomas have been recorded839 in the treatment of patients with malignant melanoma with hyperimmune serums, only a few attempts have been made deliberately to provoke the body into a defensive effort immunologically. Pack,? and Kaminsky and as-sociates6 have mentioned the possibility that rabies vaccine favorably influences the course of patients who have melanoma. With the hope that resistance could be induced, a small number of patients with generalized spread of this disease were treated with repeated infection of accessible tumors by ordinary smallpox (cowpox) vaccine. Several patients have responded favorably,2 if only temporarily, and Belisario and Milton1 using a similar technique have also reported regression of cutaneous tumors. Our case is being reported because