What does this research mean for the field?

Higher SCORE2-D scores in patients with type 2 diabetes correlate with increased coronary artery disease burden and more severe stenosis. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This study aims to evaluate the effectiveness of SCORE2-D in predicting coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM).

January 10, 2026Open Access

SCORE2-diabetes for predicting coronary artery disease: a cardiac CT study in a diabetic moderate-risk region population

RMRocco Mollace MNMatteo NardinInterventional / Structural Cardiology MAMatteo ArzentonUniversity of Ferrara

Key Result

Higher SCORE2-D scores in patients with type 2 diabetes correlate with increased CAD burden and more severe stenosis, indicating its value in risk stratification.

Key Points

This study aims to evaluate the effectiveness of SCORE2-D in predicting coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM).
Conducted a cardiac CT scan on a moderate-risk diabetic population.
Evaluated and classified coronary artery disease burden and stenosis severity.
Assessed the relationship between SCORE2-D scores and plaque features.
Higher SCORE2-D scores correlate with greater CAD burden.
More severe stenosis is observed in individuals with increased SCORE2-D scores.
High-risk plaque features are predominant in patients with elevated SCORE2-D scores.

Structured PICO

Does the SCORE2-Diabetes risk score correlate with the presence, severity, and morphology of coronary artery disease on CCTA in patients with type 2 diabetes?

Population

104 adults (aged 40-69 years) with established type 2 diabetes mellitus (T2DM) and no prior history of ASCVD referred for CCTA due to symptoms suggestive of stable CAD. Mean age 60.7 years, 69% male. Single-center in Italy. Key exclusions: prior MI, PCI, CABG, or documented coronary plaques.

Intervention

SCORE2-Diabetes (SCORE2-D) risk score calculation

Comparator

Comparison across SCORE2-D risk categories (low, moderate, high, very high)

Outcome

Presence, morphology (calcific vs non-calcific), and severity of coronary plaques assessed by coronary computed tomography angiography (CCTA)surrogate

The SCORE2-Diabetes risk score significantly correlates with the presence, severity, and vulnerability of coronary plaques on CCTA, suggesting its utility in refining pre-test probability for CAD in diabetic patients.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Higher SCORE2-D scores correlate with greater CAD burden, more severe stenosis, and a predominance of high-risk plaque features in patients with T2DM. These findings suggest that SCORE2-D may be a valuable tool in refining cardiovascular risk stratification and guiding clinical decision-making in diabetic populations.

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