What type of study is this?

This is a Cohort Study study (also classified as: Pre-Registered Trial, Validation Study).

January 14, 2026Open Forum Infectious Diseases0 citationsOpen Access

P-2201. The Burden of Influenza on Health-Related Quality of Life and Work Productivity During the First Week of Infection Among US Adults: An Interim Analysis of a Nationwide Prospective Study

THTianyan Hu AYAlon Yehoshua JCJoseph C Cappelleri

Key Points

The aim is to assess the impact of influenza on health-related quality of life and work productivity in adults during the first week of infection.
Prospective analysis in symptomatic adults with test-confirmed influenza
Participants completed questionnaires on socio-demographics and clinical characteristics
Health-related quality of life and work productivity assessed using validated instruments (EQ-5D-5L, WPAI-GH)
Outcomes compared between pre-infection baseline and Week 1 using descriptive statistics and paired t-tests.
Mean age of participants was 42.0 years, with 73.8% female and 47.1% having at least one comorbidity.
Health-related quality of life decreased significantly at Week 1, with EQ-VAS scores dropping from 89.7 to 84.9.
Work productivity time loss averaged 55.0%, absenteeism 33.2%, and presenteeism 42.2% at Week 1, all showing significant declines.

Abstract

Abstract Background This study characterized Health-Related Quality of Life (HRQoL) and Work Productivity and Impairment (WPAI) among outpatient symptomatic adults during the first week of a test-confirmed influenza infection in the US in the 2024/25 respiratory season. Methods Symptomatic adults with test-confirmed influenza infection were enrolled at CVS Health between 10/24/2024-4/15/2025 (CT.gov: NCT05160636). Questionnaires on socio-demographics and clinical characteristics were administered to participants via an online survey platform at enrollment. Validated instruments (EQ-5D-5L, WPAI-GH) were used to assess HRQoL and WPAI for the pre-infection baseline (through recall at enrollment) and at Week 1. Outcomes were summarized using descriptive statistics for each time point and compared between time points using paired t-tests. Results Of 720 participants, mean age was 42.0 (SD: 13.0), 73.8% were female, 47.1% had at least one comorbidity, and 588 (81.7%) were employed at baseline. The mean (SD) of EQ-Visual Analogue Scale (EQ-VAS) and Utility Index (UI) scores were 89.7 (SD: 7.8) and 0.96 (SD: 0.07), respectively, at the pre-infection baseline. Both scores statistically significantly decreased to 84.9 (SD: 11.0) for EQ-VAS and 0.94 (SD: 0.10) for UI scores at Week 1, with a mean change of -4.9 (p 0.001) for EQ-VAS, and -0.02 (p 0.001) for UI scores. Relative to baseline, the mean changes at Week 1 were all statistically significant, with 55.0% (p 0.001) in work productivity time loss, 33.2% (p 0.001) in absenteeism, 42.2% (p 0.001) in presenteeism, and 45.3% (p 0.001) in activity impairment. Conclusion Influenza infections negatively impacted the health-related quality of life and especially work productivity among US adults during the 2024/25 season up to the first week of infection. These findings underscore the broad and lasting consequences of influenza infections and help raise awareness of the value of preventive measures such as influenza vaccination. Disclosures Tianyan Hu, PhD, Pfizer: Salary|Pfizer: Stocks/Bonds (Public Company) Alon Yehoshua, PharmD, MS, Pfizer Inc: Employee of Pfizer and may hold stock or stock options of Pfizer Joseph C. Cappelleri, PhD, Pfizer Inc.: Employee|Pfizer Inc.: Stocks/Bonds (Public Company) Meghan Gavaghan, MPH, Pfizer Inc.: Employee Manuela Di Fusco, PhD, Pfizer Inc: Employee of Pfizer and may hold stock or stock options of Pfizer Xiaowu Sun, PhD, CVS Health: Employee|CVS Health: Stocks/Bonds (Public Company)

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