What question did this study set out to answer?

The study aims to explore the effects of mirabegron on right ventricular function in a rat model of pulmonary hypertension.

January 14, 2026Open Access

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Beta‐3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline‐Induced Pulmonary Hypertension Model

PMPedro Mendes‐FerreiraInserm BTBirger TielemansUniversitätsklinikum Aachen AWAllard WagenaarKU Leuven

Key Points

The study aims to explore the effects of mirabegron on right ventricular function in a rat model of pulmonary hypertension.
Utilized a rat model induced by monocrotaline to replicate pulmonary hypertension.
Administered high doses of mirabegron to evaluate its effects on cardiac function.
Assessed endothelium-dependent relaxation in isolated pulmonary arteries.
High-dose mirabegron significantly improved right ventricular function.
Mirabegron enhanced endothelium-dependent relaxation in isolated pulmonary arteries.

Abstract

ABSTRACT Considering the beta‐3 adrenoceptor agonist, mirabegron, may display vasodilator and cardioprotective properties, we investigated the therapeutic potential of mirabegron in monocrotaline‐induced pulmonary hypertension in rats. High‐dose mirabegron improved right ventricular function, and endothelium‐dependent relaxation in isolated rat pulmonary arteries, suggesting that mirabegron may be beneficial in pulmonary arterial hypertension.

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Beta‐3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline‐Induced Pulmonary Hypertension Model

Key Points

Abstract

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