Abstract Purpose Given obesity’s rising prevalence and its established role as an independent thromboembolic risk factor, potentially inducing a procoagulant state post-trauma, this study aimed to pinpoint key obesity-related factors influencing thromboembolic occurrences in this vulnerable patient group to guide interventions. Methods This retrospective study analyzed a consecutive cohort of 1547 trauma patients age ≥ 18 years with an Injury-Severity-Score (ISS) ≥ 9 admitted to our level I trauma center between 01/2018 and 12/2024. Patients’ data were extracted from electronic medical records. Exclusions included pregnancy, malignant/neurodegenerative disease, prior thromboembolism, and inconclusive documentation. Risk factors and influencing factors regarding obesity to suffer post-traumatic thromboembolism were evaluated. Results Older age, higher Body Mass Index (BMI), and greater Injury Severity Score (ISS) ( p 0.05). Hemoglobin levels were significantly lower in the TE group at 0, 24 and 48 h post trauma ( p < 0.05), while International Normalized Ratio (INR) and Partial Thromboplastin Time (aPTT) did not significantly differ. Conclusion Older patient age, higher BMI, and ISS are independent predictors of post-traumatic thromboembolism. Crucially, the administration of TXA and erythrocyte concentrates, essential for acute hemorrhage control, was not associated with an increased thromboembolic risk in the obese cohort. These findings support aggressive hemostatic resuscitation in high-risk obese patients.
Erdle et al. (Tue,) studied this question.