ABSTRACT Chronic kidney injury is a cosmopolitan concern of health as it is related to high morbidity and mortality. The current study was a preclinical investigation that used a rat model to study the renal protective effect of sodium molybdate (SM) against folic acid (FA)‐induced nephropathy. Chronic kidney disease (CKD) was induced in rats by a single intraperitoneal ( i.p .) injection of 250 mg/kg FA. SM orally administered at doses of 0.1 and 0.2 g/kg/day for 35 days. SM attenuated FA‐induced chronic kidney injury that demonstrated by a significant decrease in urine total proteins/24 h, serum creatinine, urea concentrations, and LDH activity, and renal MDA concentration and elevation in renal TAC and GSH content. Furthermore, renal TNF‐α, NF‐κB, caspase‐3, α‐SMA, and hydroxyproline contents significantly reduced, meanwhile renal Bcl2 significantly increased. FA‐induced histopathological alterations were mitigated. SM's renoprotective effect against FA‐induced renal injury might be attributed to its free radical scavenger, anti‐inflammatory, antiapoptotic, and/or antifibrotic mechanisms.
Ramadan et al. (Thu,) studied this question.