Comparative Efficacy and Safety of Intramuscular Midazolam Versus Intravenous Lorazepam in Prehospital Management of Status Epilepticus: Evidence From Rampart Trial

Key Points

• The aim is to compare the effectiveness of IM midazolam to IV lorazepam in terminating seizures during status epilepticus in a prehospital setting.
• Conducted a comparative trial in prehospital settings
• Administered IM midazolam and IV lorazepam to patients
• Evaluated seizure termination rates between both treatments
• IM midazolam was found to be as effective as IV lorazepam in terminating seizures
• Administration of IM midazolam allowed for faster treatment due to easier access
• No significant differences in safety profiles between the two medications