Alterations in N6-Methyladenosine (m 6 A) Modification of mRNA in the Sclera of Form-Deprived Myopic Guinea Pig

Key Points

• The study aims to investigate the impact of m6A methylation on gene regulation during myopia progression.
• Analyzed m6A methylation in mRNA from the sclera of form-deprived myopic guinea pigs
• Identified key genes related to calcium signaling and ECM remodeling
• Examined the role of METTL14 in mediating m6A modifications
• m6A methylation was significantly altered in the sclera during myopia progression
• Key genes involved in calcium signaling and ECM remodeling were regulated by m6A modifications
• Targeting m6A may provide novel therapeutic options for myopia treatment