What question did this study set out to answer?

To develop a dual-mode biosensor using CRISPR/Cas12a for the sensitive detection of alkaline phosphatase, a key biomarker.

January 17, 2026Analytical Methods0 citations

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Dual-Mode CRISPR/Cas12a-Mediated Alkaline Phosphatase Detection (CAD) Biosensor

DCDaqi Chen BZBaian Zhu YZYuan Zhou

Key Points

To develop a dual-mode biosensor using CRISPR/Cas12a for the sensitive detection of alkaline phosphatase, a key biomarker.
Utilized CRISPR/Cas12a technology for detecting alkaline phosphatase activity.
Implemented a dual-mode readout system for increased sensitivity.
Evaluated the biosensor's performance against standard detection methods.
Achieved ultrasensitive detection of alkaline phosphatase.
Outperformed existing single-readout detection techniques.
Showed potential for broader applications in clinical diagnostics.

Abstract

Alkaline phosphatase (ALP), a crucial biomarker for hepatobiliary disorders, bone diseases, and cancer progression, demands ultrasensitive detection methods to meet clinical diagnostic requirements. Current methodologies predominantly depend on single-readout mechanisms,...

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Dual-Mode CRISPR/Cas12a-Mediated Alkaline Phosphatase Detection (CAD) Biosensor

Key Points

Abstract

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