Synthesis of CF 3 -Indene-1-ol Fused Pyridones Possessing Potent Anticancer Activities through C-H Activation-Initiated Cascade Annulation Under Redox-Neutral Conditions

Key Points

• The aim is to synthesize CF3-indene-1-ol fused pyridones and evaluate their anticancer activity.
• Cascade reaction of N-methoxy acrylamides with CF3-ynones
• Vinyl C-H activation to initiate synthesis
• Conducted under redox-neutral conditions
• Successful formation of CF3-indene-1-ol fused pyridones
• Demonstrated potent anticancer activities
• Effective under mild reaction conditions