Solid-state Conformations of Pharmaceutical Polymorphs in Solution: Validation and Invalidation by NMR?

Key Points

• The research aims to understand how different polymorphic forms of drugs influence their properties using NMR techniques.
• Utilized NMR techniques to study polymorphic forms of pharmaceuticals.
• Analyzed the solid-state conformations in solution for validation.
• Comparative studies on multiple crystalline forms to assess differences.
• Identified distinct physical and chemical properties among different polymorphs.
• Validation of several polymorphs' conformations was successfully achieved using NMR techniques.
• Certain polymorphs were invalidated as viable forms based on their properties.