Three‐Component Cascade Cyclization of Nitrones, Arylsulfonyl Azides, and Isocyanides for Synthesis of 5‐Imino‐1,2,4‐Oxadiazolidines

Key Points

• The aim is to demonstrate a novel three-component cascade cyclization to synthesize 5-imino-1,2,4-oxadiazolidines.
• Utilized Pd2(dba)3 as a catalyst at 10 mol% and phosphoramidite (±)-L13 at 20 mol%
• Performed reactions in 1,2-DCE at a temperature of 80°C
• Conducted cascade cyclization involving nitrones, arylsulfonyl azides, and isocyanides
• The cyclization reaction proceeded readily producing 5-imino-1,2,4-oxadiazolidines
• Achieved reasonable chemical yields of the target compounds
• Confirmed the structure of one compound via X-ray diffraction analysis, while others were inferred