Nitrogen-doped Hollow Carbon Nanospheres as a Delivery Platform Enhance the Availability and Therapeutic Efficacy of Curcumin in Inflammatory Bone Defect Repair

Key Points

• The central aim is to investigate how nitrogen-doped hollow carbon nanospheres can enhance the bioavailability and therapeutic efficacy of curcumin in bone repair.
• Utilized nitrogen-doped hollow carbon nanospheres for curcumin delivery.
• Assessed effects on proliferation and differentiation of bone marrow mesenchymal stem cells.
• Evaluated curcumin bioavailability in inflammatory bone defects.
• Nitrogen-doped hollow carbon nanospheres significantly increased curcumin bioavailability.
• Enhanced proliferation and differentiation of bone marrow mesenchymal stem cells observed.
• Improved therapeutic efficacy in repairing inflammatory bone defects reported.