Background: Traditional patient education often lacks personalization and effectiveness. With the rise of artificial intelligence (AI), voice cloning and large language models like ChatGPT present new opportunities for improving medical education1,2. However, their re-al-world application and comparative effectiveness remain underexplored3,4. Objective: Objective: To evaluate the effectiveness of AI-assisted medical education using voice cloning and ChatGPT, and to compare the impact of physician voice cloning versus patient’s own voice cloning on education outcomes in hospitalized patients. Methods: We conducted a prospective randomized controlled trial involving 180 hospitalized pa-tients who required medical education. Participants were randomly assigned to one of three groups: (1) traditional education group (n=60), (2) physician voice cloning educa-tion group (n=60), and (3) patient’s own voice cloning education group (n=60). All groups received standardized education content. Primary outcome was education con-tent compliance rate, evaluated using ChatGPT-4 with pre-validated prompts. Second-ary outcomes included knowledge mastery, satisfaction, treatment adherence, quality of life (SF-36), and psychological status (HADS). A dedicated pre-trial validation was performed to ensure the reliability of ChatGPT-based assessments. Results: A total of 174 participants completed the trial. Both intervention groups showed signif-icantly higher education compliance rates and satisfaction than the control group (P<.001). The patient’s own voice cloning group outperformed the physician voice cloning group in content retention (92.5% vs 86.7%), satisfaction, adherence, and qual-ity-of-life domains (P<.05). One-month follow-up revealed improved treatment adher-ence and reduced anxiety and depression in the intervention groups, especially in the patient self-voice group. ChatGPT evaluation showed high consistency with expert scoring (Kappa=0.87), indicating good reliability. Conclusions: AI-assisted education using voice cloning and ChatGPT significantly improves patient education effectiveness. Education delivered through a patient’s own cloned voice demonstrates superior outcomes compared to physician voice. ChatGPT serves as an efficient and reliable evaluation tool, supporting scalable and personalized education models in healthcare. Clinical Trial: Chinese Clinical Trial Registry, No: ChiCTR2500101882.
Sun et al. (Mon,) studied this question.