Emission tomography, including single-photon emission computed tomography (SPECT), requires image reconstruction from noisy and incomplete projection data. The maximum-likelihood expectation maximization (MLEM) algorithm is widely used due to its statistical foundation and non-negativity preservation, but it is highly sensitive to noise, particularly in low-count conditions. Although total variation (TV) regularization can reduce noise, it often oversmooths structural details and requires careful parameter tuning. We propose a Graph-Enhanced Expectation Maximization (GREM) algorithm that incorporates graph-based neighborhood information into an MLEM-type multiplicative reconstruction scheme. The method is motivated by a penalized formulation combining a Kullback–Leibler divergence term with a graph Laplacian regularization term, promoting local structural consistency while preserving edges. The resulting update retains the multiplicative structure of MLEM and preserves the non-negativity of the image estimates. Numerical experiments using synthetic phantoms under multiple noise levels, as well as clinical 99mTc-GSA liver SPECT data, demonstrate that GREM consistently outperforms conventional MLEM and TV-regularized MLEM in terms of PSNR and MS-SSIM. These results indicate that GREM provides an effective and practical approach for edge-preserving noise suppression in emission tomography without relying on external training data.
Kasai et al. (Tue,) studied this question.