Naphthoquinone-derived tridentate Ru( ii ) and Os( ii ) organometallics with exceptional cytotoxicity: synthesis, characterization, stability in aqueous solution and biological in vitro evaluation

Key Points

• The research aims to evaluate naphthoquinone-derived organometallics for their cytotoxic effects and stability.
• Synthesis of N, O, O-tridentate complexes with various alkyl groups.
• Assessment of stability in aqueous solutions.
• Biological evaluation through cytotoxicity and cellular accumulation studies.
• Analysis of effects on cell cycle dynamics and IDO inhibition.
• Certain organometallic complexes exhibited significant cytotoxicity against various cell lines.
• Stability in aqueous solutions varied with different alkyl substituents.
• Some complexes demonstrated notable cellular accumulation and impact on cell cycle progression.
• IDO inhibition was effectively observed, suggesting a potential therapeutic mechanism.