Grouping nanoparticles based on properties and transcriptomic response: Are we dealing with a single nanoform or a set of nanoforms with common pulmonary hazards?

Key Points

• The study aims to assess whether titanium dioxide nanoparticles exhibit a common toxicity profile or present distinct nanoforms with different pulmonary risks.
• Analyzed properties and transcriptomic responses of titanium dioxide nanoparticles.
• Conducted comparative assessments to group nanoparticles based on safety profiles.
• Utilized different models to evaluate pulmonary exposure responses.
• Identified variations in the transcriptomic response among different nanoforms.
• Demonstrated potential common pulmonary hazards associated with titanium dioxide nanoparticles.
• Highlighted the need for differentiated risk assessments based on nanoform properties.