Advancements in development of novel class of HIV protease inhibitors

Key Points

• The aim is to review recent developments in HIV protease inhibitors and address drug resistance issues.
• Review of current literature on protease inhibitors and their effectiveness against HIV.
• Identification of key PR mutations that lead to drug resistance.
• Analysis of novel protease inhibitor classes for their potential anti-HIV efficacy.
• Three classes of novel protease inhibitors identified for anti-HIV development.
• Novel inhibitors show activity targeting active and non-active sites of protease.
• New drugs are designed to address drug-resistant variants, enhancing treatment options.